| Name/Location | County | Open | Close | Comment |
| SADLERS ALES, Stourbridge | W Midlands | 2004 | . | Windsor Castle Brewery |
| Saddle Inn | . | . | . | See Featherstone |
| SADDLEWORTH, Uppermill, Oldham | Gtr Manchester | 1997 | . | Located at The Church Inn PH |
| SAFFRON, Henham, Bishops Stortford | Essex | 2006 | . | . |
| SAINTS & SINNERS, ? | ? | No brewery | . | Produces bottled beer at various breweries |
| Sair Inn | . | . | . | See Linfit |
| SALAMANDER, Bradford | W Yorkshire | 2000 | . | . |
| Sallies | . | . | . | See Britannia |
| SALOPIAN, Shrewsbury | Shropshire | 1995 | . | Ceased part 1997 |
| SALTAIRE, Shipley | W Yorkshire | 2006 | . | . |
| Salutation | . | . | . | See Eagles Bush |
| SAM POWELL, Newtown | Montgomeryshire | 1983 | 1991 | Plant & Brands ex Powys. See also Wood |
| Sam Trueman | . | . | . | See Trueman |
| SAMBROOKS, Battersea | London SW11 | 2008 | . | . |
| Samuel Allsopp | . | . | . | See Allsopps |
| SAMUEL SMITH, Tadcaster | W Yorkshire | 1758 | . | See also Melbourn Brothers |
| Samuel Webster | . | . | . | See Websters |
| SANDOWN, Sandown | I O W | 1996 | 1998 | Located at The Old Comical PH (ex Cask & Codpiece). Aka Burts/Hartridges. See also Ushers |
| SANDSTONE, Wrexham | Denbighshire | 2008 | . | . |
| SARAH HUGHES, Sedgley, Dudley | W Midlands | 1987 | . | Located at The Beacon Hotel. Also brewed c1860-c1957 |
| SARAH'S HOPHOUSE, Golborne, Warrington | Gtr Manchester | 1999 | 2003 | Located at The Railway Inn |
| SARK, Sark | C I | 1983 | 1983 | . |
| SAWBRIDGEWORTH, Sawbridgeworth | Hertfordshire | 2000 | . | Located at The Gate Inn. Plant ex Alford Arms |
| SAXON CROSS, Buxton | Derbyshire | 1979 | 1987 | Aka Winkles |
| SCANLON'S, Yiewsley | Middlesex | 1996 | 1997 | See also Scanlon's Fine Ales |
| SCANLON'S FINE ALES, Uxbridge | Middlesex | No brewery | ? | Formerly Scanlons. Contract brewed by Rebellion & Vale? |
| SCARECROW, Arreton | I O W | 2002 | . | . |
| SCATTOR ROCK, Christow, Exeter | Devon | 1998 | 2009 | See Gidleys |
| Scotland's Craft Brewers Co-operative | No brewery | . | ? | See Bridge of Allan & Sulwath |
| Scottish & Newcastle | . | . | . | See Scottish Courage, Home, Websters & Yorkshire Grey |
| Scottish Brewers | . | . | . | Merger of Wm McEwan & Wm Younger 1931. Merged with Newcastle Breweries 1960 to become Scottish & Newcastle |
| Scottish Courage | . | . | . | Formed by acquisition of Courage by S&N 1995 |
| SCOTTISH COURAGE, Bristol | Gloucestershire | 1730? | 2000 | Georges Brewery. Acquired by Courage 1961 and by Scottish & Newcastle 1995 |
| SCOTTISH COURAGE, Dunston, Gateshead | Tyne & Wear | 2004 | . | Dunston Brewery. Acquired from Federation Brewery |
| SCOTTISH COURAGE, Edinburgh | Midlothian | 1856 | 2004 | Wm McEwan's Fountain Brewery (rebuilt 1974). Merged with Wm Younger 1931 & with Newcastle breweries 1960 |
| SCOTTISH COURAGE, Manchester | Gtr Manchester | Reg 1933 | . | Royal brewery. Keg only (Harp Lager) |
| Scottish Courage, Masham | . | . | . | See Theakston |
| SCOTTISH COURAGE, Newcastle-upon-Tyne | Tyne & Wear | Reg 1890 | 2004 | Tyne Brewery |
| SCOTTISH COURAGE, Reading | Berkshire | 1978 | ? | Berkshire Brewery. Aka Worton Grange. Acquired from Courage by Scottish & Newcastle 1995. Keg only |
| SCOTTISH COURAGE, Tadcaster | W Yorkshire | 1757 | . | John Smith's brewery. Acquired by Courage 1970 & by Scottish & Newcastle 1995 |
| SCOTT'S, Lowestoft | Suffolk | 1988 | 1999 | Plant ex Sevenoaks. Name changed from Scotties 1992/3 |
| Sea Lion | . | . | . | See Olde Bull & Bush |
| SELBY, Selby | N Yorkshire | 1972 | . | Also brewed 1894-1954 |
| Seven Stars | . | . | . | See Bathtub |
| SEVENOAKS, Seal Chart | Kent | 1981 | 1986 | Located at The Crown Point Inn |
| SEVERN VALE, Cam, Dursley | Gloucestershire | 2005 | . | . |
| SHACKLEFORD, Shackleford | Surrey | 1992 | 1994 | Located at The Cyder House PH. See also Baynards |
| Shakespear's | . | . | . | See Bard's |
| SHALFORD, Blackmore End, Braintree | Essex | 2007 | . | . |
| SHARDLOW, Cavendish Bridge, Shardlow | Leicestershire | 1993 | . | . |
| SHARP'S, St Minver, Wadebridge | Cornwall | 1994 | . | . |
| SHAWS, Dukinfield | Gtr Manchester | 2002 | . | . |
| Sheaf of Arrows | . | . | . | See Cranborne |
| SHEFFIELD, Sheffield | S Yorkshire | 2006 | . | . |
| SHENSTONE, Lichfield | Staffordshire | Planned | . | See also: Quaffale |
| SHEPHERD & Co, Bitteswell | Leicestershire | 1998 | . | Ex Man in the Moon. No Real ale |
| SHEPHERD NEAME, Faversham | Kent | 1698 | . | IFBB Member |
| SHERBORNE, Sherborne | Dorset | 2005 | . | Plant ex Happy Hooker |
| Sherwood Forest | . | . | . | See Bateman |
| Ship | . | . | . | See Solva |
| Ship & Plough | . | . | . | See Blewitt's |
| SHIPSTONE, Basford, Nottingham | Nottinghamshire | 1852 | 1991 | Star Brewery. Aka James Shipstone. Acquired by Greenalls 1978 |
| SHIRES, Madeley | Shropshire | 2009 | . | Located at The All Nations Brewhouse. Formerly Worfield |
| SHIRES, Shefford | Bedfordshire | 1995 | 1996 | Plant ex Judges |
| SHOES, Norton Canon | Herefordshire | 1994 | . | Located at The Three Horseshoes PH. Malt extract plant |
| Shore Hotel | . | . | . | See Old Laxey |
| SHOTOVER, Horspath, Oxford | Oxfordshire | 2009 | . | . |
| SHRALEY BROOK, Shraley Brook | Staffordshire | 1998 | 2001 | Site & plant leased from Rising Sun |
| Shrewsbury & Wem | . | . | . | See Wem |
| SHUGBOROUGH, Milford | Staffordshire | 1996 | . | Staffordshire County Museum. Occasional brews by Titanic. Also brewed 1990 |
| SIDECAR, Huddersfield | W Yorkshire | 2005 | 2006 | Uses Golcar plant |
| SILVER STREAM, Horsham | W Sussex | 2001 | 2004 | Used Hepworth plant occasionally |
| SILVERSTONE, Snesham, Brackley | Northamptonshire | 2008 | . | Plant ex Fen Ales |
| SILVERTHORNE GWENT ALES, Pontnewdd | Monmouthshire | 1984 | 1985 | Ex Gwent Ales. Moved to Lamb Inn (Pontynewdd?) |
| SIMMONDS, Reading | Berkshire | 1768 | 1979 | Acquired by Courage 1960 |
| SIMON'S TOWER BRIDGE, Southwark | London SE1 | 1980 | 1981 | See also Bridge House |
| SIMPKISS, Brierley Hill | W Midlands | 1919 | 1985 | Dennis Brewery. Aka JPS. Acquired by Greenalls 1985. See also Enville. |
| Simpson & Simpson | . | . | . | See Brown Cow |
| SINCLAIR BREWERIES, Cawdor | Nairn | No brewery | . | Acquired Atlas & Orkney (Highlands & Islands Breweries) 2006 |
| Sir William Peel | . | . | . | See Old Stables |
| SIX BELLS, Bishops Castle | Shropshire | 1997 | . | Located at The Six Bells PH. Also brews for Ystwyth Ales |
| SKINNER'S, Truro | Cornwall | 1997 | . | Plant ex Aberdeenshire |
| SLATER'S, Stafford | Staffordshire | 1994 | . | Moved from The George Inn, Eccleshall 2006. Aka Eccleshall |
| SLAUGHTERHOUSE, Warwick | Warwickshire | 2003 | . | Plant ex Church End |
| Sligachan Hotel | . | . | . | See Cuillin |
| SMALL PAUL'S, Gillingham | Dorset | 2006 | . | . |
| SMILES, Bristol | Gloucestershire | 1977 | 2004 | Moved from Bells Diner 1978 & name changed from Paynes |
| SMILES BREWING, Bristol | Gloucestershire | No brewery | . | Set up to market Smiles beers brewed by Highgate |
| Smith (John) | . | . | . | See Scottish Courage, Tadcaster |
| Smith (Samuel) | . | . | . | See Samuel Smith |
| SNOWDONIA, Gellilydan, Blaenau Festiniog | Merionethshire | 1992 | 1995 | Aka Barrys/Bryn Arms |
| SNOWDONIA, Waunfawr | Caernarvonshire | 1998 | . | Located at The Snowdonia Park Hotel |
| Soho Brewing Co | . | . | . | See Freedom |
| Sole Bay Brewery | . | . | . | See Adnams |
| SOLSTICE, Kington | Herefordshire | 1993 | 1995 | Former Dunn Plowman plant. Located at The Queens Head PH. Plant sold to Marches |
| SOLVA, Haverfordwest | Pembrokshire | 1993 | 1996 | Located at The Ship PH |
| SOMERSET (ELECTRIC), Halse, Taunton | Somerset | 2003 | 2005 | Located at The New Inn. See also Taunton |
| SON of SID, Little Gransden, Sandy | Cambridgeshire | 2007 | . | Located at The Chequers PH |
| South Eastern | . | . | . | See Hilton |
| SOUTH HAMS, Stokeley Barton, Stokenham, Kingsbridge | Devon | 2004 | . | Formerly Sutton then Stokeley |
| South Yorkshire | . | . | . | See Barnsley |
| Southern Brewers | . | . | . | See Pig & Whistle |
| SOUTHPORT, Blowick, Southport | Merseyside | 2004 | . | Plant ex Banfield/Buntingford/3 Rivers |
| SOUTHSEA, Portsmouth | Hampshire | 1982 | 1985 | Aka Old Lion |
| Southwick Brewhouse | . | . | . | See Golden Lion |
| S P SPORTING ALES, Stoke Prior, Leominster | Herefordshire | 1996 | 2001? | Plant sold to Dunn Plowman, Kington |
| Spa Brewery | . | . | . | See Royal Tunbridge Wells |
| SPECTRUM, Tharston, Norwich | Norfolk | 2007 | . | Organic beers. Used Blue Moon plant 2002-7 |
| Speedwell Inn | . | . | . | See Townes |
| SPIKES, Southsea | Hampshire | 1994 | 2000? | Located at The Wine Vaults PH |
| SPINNAKER, Lancing | W Sussex | 1993 | 2001? | Plant ex Dickens. Formerly Brewery on Sea. Also brews for East West Ales |
| SPINNING DOG, Hereford | Herefordshire | 2000 | . | Located at The Victory PH (ex Jolly Roger site). Brewing ex Flannery's brands? |
| SPIRE, Staveley, Chesterfield | Derbyshire | 2006 | . | . |
| SPITTING FEATHERS, Waverton, Chester | Cheshire | 2005 | . | Also uses name Cestrain Brewery |
| Springfield Brewery | . | . | . | See Bass, Wolverhampton |
| SPRINGHEAD, Sutton-on-Trent, Newark | Nottinghamshire | 1990 | . | Moved 1994. Ceased part 1997/8 |
| St AUSTELL, St Austell | Cornwall | 1860 | . | Also brews for ex-Ferguson. IFBB Member |
| St Clements | . | . | . | See First in Last Out |
| St Edmunds Head | . | . | . | See Old Cannon |
| St GEORGE'S, Callow End, Worcester | Worcestershire | 1998 | . | . |
| St GILES IN THE WOOD, Great Torrington | Devon | 1998 | 1999 | Plant ex Sutton. See also Clearwater |
| St Helens College | . | . | . | See Beecham's |
| St JUDES, Ipswich | Suffolk | 2006 | . | . |
| St PETER'S, South Elmham, Bungay | Suffolk | 1996 | . | . |
| Stable Brewery | . | . | . | See Maldon Brewing |
| STABLES, Beamish, Stanley | Co Durham | 1990 | . | Located in the grounds of Beamish Hall Country House Hotel |
| Stables Brewery | . | . | . | See Humpty Dumpty |
| Stag Tavern, Stotford | . | . | . | See Abel Brown's |
| Stag Tavern, Stowmarket | . | . | . | See Bury Street |
| STAG & GRIFFIN, Tatling End, Gerrards Cross | Buckinghamshire | 1996 | 1997 | Moved to Viking, Broadstairs |
| Stag & Hounds | . | . | . | See Parish & John o'Gaunt |
| Stag Brewery | . | . | . | See Watneys, Mortlake |
| STALLION ALES, Helland, Bodmin | Cornwall | 1983 | 1987 | Moved from Long Barn, Cippenham 1985 |
| STANWAY, Cheltenham | Gloucestershire | 1993 | . | . |
| Star | . | . | . | See Tipsy Toad, St Peter's Village |
| STAR BEERMAKING, Steeple | Essex | 2005 | 2007 | . |
| Star Brewery | . | . | . | See Ind Coope, Romford |
| Star Brewery | . | . | . | See Shipstone |
| STAR, Cambridge | Cambridgeshire | 1822 | 1972 | Acquired by Tolly Cobbold 1934 |
| STAR, Norwich | Norfolk | 1981 | 1982 | Located at The Golden Star PH. Aka Turners Star. Plant sold to Fox & Hounds, Barley |
| STARKEY, KNIGHT & FORD, Tiverton | Devon | 1852 | 1982 | Acquired by Whitbread 1962 |
| Station Brewery | . | . | . | See Richmond |
| Station Hotel | . | . | . | See Easingwold |
| Stationhouse | . | . | . | See Frodsham |
| STATION INN, Guiseley | W Yorkshire | 1982 | 1987 | Allied (Tetley) pub brewery |
| STEAM PACKET, Knottingley | W Yorkshire | 1990 | 1998 | Plant moved to Kent Garden |
| STEAMBOAT, Sawley | Nottinghamshire | 1987 | 1989 | Closed 1991? |
| STEAMIN' BILLY, Oadby | Leicestershire | No brewery | . | Beers originally brewed by Leatherbritches, from 1999 by Grainstore & Belvior, from 2007 by Tower |
| STEEL CITY, Sheffield | S Yorkshire | No Brewery | . | Uses Brew Company or Little Ale Cart plant |
| STEWART, Edinburgh | Midlothian | 2004 | . | . |
| STICKLEGS, Elmstead Market, Colchester | Essex | 2008 | . | Moved from The Cross Inn, Market Bromley 2010 |
| Stirling | . | . | . | See Traditional Scottish Ales |
| STOCKS, Doncaster | S Yorkshire | 1981 | 1996 | Located at The Hallcross PH. Closed by Century Inns. See also Hull |
| Stokeley | . | . | . | See South Hams |
| STONEHENGE, Netheravon, Salisbury | Wiltshire | 1984 | . | Plant ex Swimbidge. Ownership & name changed from Bunces 1993 |
| STONEHOUSE, Weston, Oswestry | Shropshire | 2007 | . | . |
| STONES, Sheffield | S Yorkshire | 1898 | 1999 | Aka William Stones. Acquired by Bass 1968 |
| STONY ROCK, Waterhouses, Stoke on Trent | Staffordshire | 1997 | 2000 | . |
| STORM BREWING, Macclesfield | Cheshire | 1998 | . | Originally named Bollin? |
| Storyteller | . | . | . | See The Storyteller |
| STOWEY, Nether Stowey, Bridgewater | Somerset | 2006 | . | . |
| STRANDS, Nether Wasdale, Seascale | Cumbria | 2007 | . | Located at The Strands Hotel. Plant ex Saddleworth |
| Strangeways Brewery | . | . | . | See Interbrew Manchester |
| STRANGFORD LOUGH, Killyleagh, Downpatrick | N Ireland | No brewery | . | Contract brewed by Whitewater? |
| STRATHALBYN, Dalmuir | Dunbartonshire | 1982 | 1987 | . |
| STRATHAVEN, Craigmill, Strathaven | Lanarkshire | 2005 | . | Craigmill Brewery. Site ex Heather Ale |
| STRAWBERRY BANK, Strawberry Bank | Cumbria | 1997 | 2000? | Masons Arms pub brewery. Former home of Lakeland Brewing Co. |
| STREETS OF LONDON, East Molesey | Surrey | 1982 | 1984 | Whitbread pub brewery |
| STRINGERS BEER, Ulverston | Cumbria | 2008 | . | . |
| STRONG, Romsey | Hampshire | 1858 | 1981 | Horsefair Brewery. Acquired by Whitbread 1969 |
| STROUD, Thrupp, Stroud | Gloucestershire | 2006 | . | . |
| STUDLEY, Studley | Warwickshire | 1978 | 1982 | Part of Seven Wonders Inns |
| STUMPY'S, Newchurch, Sandown | I o W | 2004 | 2008 | Brewed at Upper Swanmore, Southampton 2004-08. See also Yates' |
| STYLE & WINCH, Maidstone | Kent | 1806 | 1971 | Acquired by Barclay Perkins (Courage) 1929 |
| Suddaby's Crown Hotel | . | . | . | See Malton |
| SULWATH, Castle Douglas | Kirkcudbrightshire | 1997 | . | Moved from Southerness 2000 |
| SUMMER WINE, Honley | W Yorkshire | 2006 | . | Moved from Brockholes, Holmfirth 2007 |
| SUMMERSKILLS, Plymouth | Devon | 1983 | . | Plant part ex Penrhos. Moved from Bigbury on Sea 1985. Ceased part 1989-90 |
| Sun Inn | . | . | . | See Corvedale |
| Sunset Cider & Wine Ltd | . | . | . | See Egyptian Sand & Gravel |
| SURREY HILLS, Shere, Guildford | Surrey | 2005 | . | . |
| Surtees Arms | . | . | . | See Yard of Ale |
SUSSEX, Pett | E Sussex | 1998 | 2004 | Site & plant ex Pett. Formerly Old Forge then Forge. Located opposite The Two Sawyers PH |
| Sussex Brewery P H | . | . | . | See Hermitage |
| SUSSEX, Pulborough | W Sussex | 1980 | 1983 | Ownership change/moved from Edburton, Nr Poynings 1982 |
| SUTHERLAND, Edinburgh | Midlothian | 1996 | 1997 | . |
| SUTHWYK ALES, Suthwick, Fareham | Hampshire | No brewery | . | Brewed by Oakleaf using barley from Southwick |
| SUTTON, Plymouth | Devon | 1994 | 2004 | See also South Hams |
| SWALE, Grafty Green | Kent | 1995 | 2003 | Moved several times & became Tun, Vine & Press 2000-01. Plant sold to Whitstable. Beers contract brewed by Archers? |
| SWALED ALE, Gunnerside, Richmond | N Yorkshire | 1995 | 2001? | . |
| Swan PH | . | . | . | See John Joules & Son |
| Swan on the Green | . | . | . | See Swan |
| SWAN, West Peckham, Maidstone | Kent | 2000 | . | Located at The Swan on the Green PH. Aka Gimbal Trading |
| Swannay Brewery | . | . | . | See Highland |
| SWANNELLS, Kings Langley | Hertfordshire | 1982 | 1983 | . |
| SWANNELLS, Kings Langley | Hertfordshire | 1982 | 1983 | . |
| SWANSEA, Bishopston, Swansea | Glamorgan | 1996 | . | Located at The Joiners Arms PH |
| SWATON, Swaton, Sleaford | Lincolnshire | 2007 | . | . |
| SWEET WILLIAM, Leyton | London E10 | 2000 | 2005 | Located at The William IV PH. See also Brodies Beers |
| SWIMBRIDGE, Barnstable | Devon | 1981 | 1983 | . |