| Name/Location | County | Open | Close | Comment |
| UFFORD ALES, Ufford, Stamford | Cambridgeshire | 2005 | . | Located at Ye Old White Hart PH. Owns Tyddford Ales with Tydd Ales |
| ULEY, Uley, Dursley | Gloucestershire | 1985 | . | . |
| ULVERSTON, Lindal, Ulverston | Cumbria | 2006 | . | Plant ex Whitley Bridge. Office at Ulverston |
| UNCLE STUART'S, Lingwood, Norwich | Norfolk | 2002 | . | . |
| Unicorn Brewery | . | . | . | See Robinsons |
| UNICORN, Ketley | Shropshire | 1986 | 1988 | . |
| UNION, Hayes | Middlesex | 1982 | 1983 | Aka B & W Beer Co |
| UNION, Holberton, Plymouth | Devon | 2005 | . | Located at The Dartmoor Union Inn |
| UNtapped, Cardiff | Glamorganshire | No brewery | . | Beers brewed at Whittington |
| UPHAM, Upham, Bishops Waltham | Hampshireshire | 2010 | . | . |
| Upper Agbrigg | . | . | . | See Holme Valley |
| USHERS, Edinburgh | Midlothian | 1817 | 1981 | Acquired by Allied (Tetleys) 1980 |
| USHERS, Trowbridge | Wiltshire | 1824 | 2000 | Management buyout 1991 ex Courage. Also owned Burts brands. & brewed for Gibbs Mew. Closed by InnSpired. |